间变性大细胞淋巴瘤课件（英文）.pptx

Anaplastic Large Cell LymphomaVose, J. et al. Journal of Clinical Oncology 26(25): 4124-4130.Vose, J., J. Armitage, et al. (2008). Journal of Clinical Oncology 26(25): 4124-4130.Anaplastic Large Cell Lymphoma：间变大细胞淋巴瘤异型性是肿瘤组织和细胞出现成熟障碍和分化障碍的表现。异型性越大，成熟程度和分化程度就越低。有些恶性肿瘤细胞分化很差，异型性显著，称为间变性肿瘤（ Anaplastic neoplasma）。间变性的肿瘤细胞常就有多形性（pleomorphism），即肿瘤细胞的大小和形状变异很大。间变性肿瘤多为高度恶性的肿瘤。病理学（第六版）人民卫生出版社。P96Anaplastic Large Cell Lymphoma：间变大细胞淋巴瘤Anaplastic :间变恶性肿瘤失分化，异型性显著病理学（第六版）人民卫生出版社。P96Chiarle, R., C. et al. (2008). Nat Rev Cancer 8(1): 11-23.S-ALCL占成人NHL的2%-3%，儿童NHL的10-15%；分为ALK+与ALK-亚型C-ALCL占皮肤淋巴瘤的8%，男性多见Fatusi, O.et al. Journal of Oral and Maxillofacial Surgery 68(4): 884-888.Querfeld, C. et al. Oncology (Williston Park) 24(7): 574-587Lamant, L. et al. (2007). Blood 109(5): 2156-2164.标志性细胞形态：细胞体积大，胞质丰富，呈弱嗜碱性或双性染色，有一偏心细胞核、呈马蹄形或肾形、凹面向心并部分围绕Golgi区、常含有多个较小的嗜碱性核仁，胞膜和高尔基体体高表达CD30，表达ALK蛋白，而且ALCL细胞生长具有内聚性，具有向淋巴窦浸润的倾向Jacobsen, E.. The Oncologist 11(7): 831-840.临床及病理特点Querfeld, C. et al. Oncology (Williston Park) 24(7): 574-587.临床及病理特点Savage, K. J et al. Blood Reviews 21(4): 201-216.临床及病理特点primary cutaneous CD30-positive lymphoproliferative disorders:c-ALCL andlymphomatoid papulosisSavage, K. J et al. Blood Reviews 21(4): 201-216.European Organization for Research and Treatment of Cancer (EORTC), International Society of Cutaneous Lymphoma (ISCL) and United States Cutaneous Lymphoma Consortium (USCLC) consensus recommendations for the treatment of primary cutaneous CD30-positive lymphoproliferative disorders: lymphomatoid papulosis and primary cutaneous anaplastic large-cell lymphomaKempf, W., K. Pfaltz, et al. (2011).Blood.OnlineALCL：形态特征占10%占70%占5%-10%de Leval, L et al. Hematology 2008(1): 272-279Webb, T. R.et al. Expert Rev Anticancer Ther 9(3): 331-356.de Leval, L. and P. Gaulard (2008). Hematology 2008(1): 272-279Molecular network interacting with NPM-ALK.ALK and Ras–ERKALK and STATsALK and PI3KAmin H M , Lai R Blood 2007;110:2259-2267?2007 by American Society of Hematology预后：Media