cellular effects of sildenafil viagra西地那非细胞效应.pdf

CanonicalPathway

ReportDate:2016-01-20

ReportVersion:FFFF.svnRevision.FFFF

ContentVersion:(ReleaseDate:2015-11-30)

CanonicalCellularEffectsofSildenafil(Viagra)

Pathway:

Description:ErectileDysfunction(ED),alsoknownasimpotence,affectsalargesegmentofthemalepopulationover40yearsofage.EDresultsfromimpaired

relaxationofthesmoothmusclecellsinthecorpuscavernosumandinthepenilearteries.Uponualstimulation,theincreaseinparasympatheticactivity

resultsindilationofthecavernosalarteriesandincreasedbloodflow.Atthesametime,relaxationofthetrabecularsmoothmuscleincreasesthe

complianceofthecavernousspaces,whichfacilitatesbloodflow.Theincreaseinbloodvolumeandthecompressionoftherelaxedtrabecularmuscle

againstthetunicaalbuginearesultsincollapseofthevenulesandobstructionofvenousoutflow.Oncethisoccurs,bloodceasestoflowthroughthe

cavernosalarteries,andarigiderectionoccurs.Themajormediatorofrelaxationofthesmoothmusclecellsinthecavernosalarteriesandthetrabecular

muscleisnitricoxide(NO).

Uponualstimulation,NOisproducedbyeNOSinotheliumofthepenileandcavernosalarteries,andbyNNOSinthenon-adrenergic/non-

cholinergicnerveterminals(NANC)thatdenselyinnervatethecorpuscavernosum.ualstimulationalsoenablesthereleaseofneurotransmitters,