NF-κBp50、JAB1和CRM1在弥漫性大B细胞淋巴瘤中的表达及其意义.pdf

·92· ·临床医学· 周永清，柴琳 (皖南医学院医学三系，安徽芜湖241002) andCRMl in NF-,dip50，JABlexpression diffuseBcell andtheirclin· large lymphoma ical significance ZHOU Yong—qi，皤，CHA／L／n ofClinieel Medical 11I洲DepartmentMedicine，WannanCollege，Wuhu 241002，China the ofnuclear lAbstract】Objective：Toinvestigate expression factor-娜 andCRMlindiffuse Bcell 起着重要的作用 paB(NF—zBpso)，JABl large lym小oma (DLBCL)andthorclinicalsignificance．Methods：lramunohistochemie丑l WBSusedtodetectthe of and 免疫组织化学 technique exprvssionNF—KBp．S0，JABI CRMIin 94ⅢofDLBCL．Resu／ts：Thepositiverat∞0f NF-gBpS0． 733．1 【中图号】R 【文献标识码】A andCRMlinDLBCL JABI wc70．2％(66／舛)，77．7％(73／94)and 【DOIl 10．3969／j．issn．10024)217．2012．02．003 in 69．1％(65／94)．respectively．NF—KBp50expressionn∞-germinal cedarB-cell ofDLBCL thanthatin B．cell C,CB 弥漫性大B细胞淋巴瘤(diffuse like(non-GCB)typew¨higher large W88 the type。which different(P0．01)。whereasexpression statistically of with JABIandCRMlhadnocorrelationthe of typingDLBCL(P notassociated and wm with 0．05)．NF—KBpSO．JABICRMIexpression 我国等发展中国家发病率则更高一些。其在病理学 and locationof sexes，agesoncogenie DLBCL(P0．05)，though．there wa5a correlationbetween inDL- 特征、生物学行为和临床表现上都具有显著的异质 andJABIorCRMi positive NF-KBpS0 性，是一组高度异质性B